NF-κB plays a crucial role in the expression of proinflammatory molecules such as cytokines, chemokine, and adhesion molecules (Dinh and Lewis, 2019) and several studies have demonstrated its involvement in metabolic disorders and atherosclerosis (Di Tomo et al., 2012), phenomena that could be prevented or ameliorated by several pharmacological or natural approaches (Di Pietro et al., 2020). The gene discussed is NFKB1; the disease is atherosclerosis.