Tumor-targeted and MMP-2 activatable nanoprobe (TMAN): Gd/CuS nanodisks encapsulated into micelles using DSPE-PEG2000, and then functionalized with an αvβ3 tumor-targeting group (cRGDSH) and a Cy5.5- and QSY21-labeled MMP-2 cleavable peptide substrate ((QSY21)-GGPLGVRGK(Cy5.5)-SH Shi et al. (2019). The gene discussed is MMP2; the disease is neoplasm.