GRK4 and hypertensive disorder: It was observed that pharmacogenetic variants, rs1024323 and rs1801058 (F110V, A142V, Y292A, V486A, and F454A) evoked a phenotypic effect (Hypertension, Nephrosclerosis and Kidney issues) on the interaction between GRK4 gene and Metoprolol drug (Supplementary Table S9).