SGLT-2i have a special hypoglycemic pathway, which does not rely on insulin, but reduces the glucose reabsorption by the proximal renal tubules, resulting in increased excretion of glucose from the urine, thereby controlling the blood glucose of patients with T2DM (Das et al., 20202020; Weng et al., 2021). The gene discussed is INS; the disease is type 2 diabetes mellitus.