Normal T-cell development Kwon et al. (2002); Decreased CD8 T cell number Steinhilber and Stegmeyer (1977), Increased CD4 T-cell infiltration Vinay et al. (2007); Reduced number of NK and NKT cells; resistance to LPS-induced shock syndrome Vinay et al. (2004); Increased number of myeloid progenitor and mature DCs; impaired DC function Lee et al. (2008); Reduced atherosclerosis in hyperlipidemic mice Jeon et al. (2010). This evidence concerns the gene CD8A and atherosclerosis.