REN and acute kidney injury: After diuretics and renin-angiotensin drugs, the most frequently involved drug classes were antibiotics in the HA-AKI subgroup (13.0%), when the main suspected drugs were furosemide in diuretics class, ramipril in renin-angiotensin drugs class and sulfamethoxazole-trimethoprim in antibiotics class (Figure 3 and Supplementary Table S5).