Wang et al. identified novel poricoic acids from Poria cocos and found that they attenuated renal fibrosis through the modulation of AHR signaling pathway in TGF-β1-induced cultured human kidney proximal tubular epithelial cells and mice with unilateral ureteral obstruction (Wang M. et al., 2020). The gene discussed is AHR; the disease is Ureteral obstruction.