p62 has been reported to control IFN antiviral responses by promoting autophagic degradation of several key factors in the IFN pathway, including RIG-I, cGAS, MAVS, and IRF3 during viral infection (Xian et al., 2020; Liu et al., 2021; Xie et al., 2022b). Here, IRF3 is linked to viral infectious disease.