Numerous studies have been attempted to link AD-related molecules to the pathogenesis of AD: APOE ε4-associated mechanisms (Yamazaki et al., 2019) such as Aβ clearance and aggregation, cerebral energy metabolism, neuroinflammation, neurovascular function, and synaptic plasticity, and presenilin-related ones such as Aβ production (Selkoe and Hardy, 2016), calcium homeostasis (Honarnejad and Herms, 2012) and neurogenesis (Hernandez-Sapiens et al., 2022). This evidence concerns the gene APOE and Alzheimer disease.