Table 5 shows the genotypes and allele frequencies of these four loci in different sex subgroups of HT patients. The genotype distribution of rs3775194 in male HT patients (CC 1.5%, GG 87.7%, and CG 10.8%) was significantly different from that in male control group (GG 78.2% and CG21.8%) (P = 0.048), but there were no positive results in allele frequency between the two groups. We have not yet found an association between VEGFC loci and female AITD patients (Table 6). This evidence concerns the gene VEGFC and hematocrit.