Using native RIP, Chu et al. found that EZH2 histone methyltransferase suppresses PHACTR2-AS1 expression in BC cells, with PHACTR2-AS1 depletion leading to hyperactivation of ribosome synthesis and ribosomal DNA instability, which promotes cancer cell proliferation and metastasis (Chu et al., 2020). The gene discussed is EZH2; the disease is breast cancer.