ZNF217 and neoplasm: In addition to DNA methylation, EPB41L4A-AS2 is also regulated by ZNF217 (zinc finger protein 217)-mediated H3K27me3 (trimethylation of lysine 27 on histone 3), which contributes to inhibited expression of this lncRNA, thus limiting its tumor suppressor activity (Pang et al., 2019).