EZH2 and breast cancer: Last but not least, coming into interactions with chromatin-modifying enzymes not only serves scaffolding and recruitment functions but also may lead to degradation of the proteins and their complexes, as is the case in ANCR, which affects EZH2 stability and inhibits epithelial-mesenchymal transition (EMT), invasion, tumorigenesis and distant metastasis in BC (Li Z. et al., 2017).