The recruitment of the hnRNPL-LINC02273 complex to the promoter of AGR2 (anterior gradient 2, a disulfide isomerase associated with decreased breast cancer survival) increases local H3K4me3 and H3K27 acetylation, thereby epigenetically upregulating AGR2 and promoting BC metastasis. The gene discussed is TXNDC15; the disease is breast cancer.