All the detected GPCRs in the cavernous hemangioma (ADRA1D, ADRA2B, ADRA2C, AVPR2, CNR1, GALR1, GPR20, LPAR4, OXTR, P2RY2, TACR1, CYSLTR1, TAS1R1, TAS2R43, MAS1, GPR156, P2RY8, GPR52, and GPR85) were expressed at markedly higher levels in EC1 than EC2 (Supplementary Figure S17). Here, ADRA2C is linked to cavernous hemangioma.