All the detected GPCRs in the cavernous hemangioma (ADRA1D, ADRA2B, ADRA2C, AVPR2, CNR1, GALR1, GPR20, LPAR4, OXTR, P2RY2, TACR1, CYSLTR1, TAS1R1, TAS2R43, MAS1, GPR156, P2RY8, GPR52, and GPR85) were expressed at markedly higher levels in EC1 than EC2 (Supplementary Figure S17). This evidence concerns the gene P2RY2 and cavernous hemangioma.