Based on the above results, we concluded that: 1) proinflammatory cytokines and related genes TNF, TNFSF13B, TNFRSF12A, TNFAIP6, and C1QTNF6 are significantly involved in the MSC-induced immune responses in cavernous hemangiomas; 2) UCHL1 is up-regulated in the embryonic MSC apoptosis induced by proinflammatory cytokines (e.g., TNF and TNFSF13B); and 3) UCHL1 can be used as a marker gene to detect embryonic MSCs at different apoptosis stages. The gene discussed is TNFRSF12A; the disease is cavernous hemangioma.