More than 100 loci and 88 genes are implicated in the pathogenesis of HSP, being SPAST, the gene that encodes for the protein spastin, the most frequently mutated HSP gene (termed HSP-SPG4), accounting for more than 50% of autosomal dominant familial and 20% of sporadic HSP cases (Chaudhary et al., 2022). This evidence concerns the gene SPAST and hereditary spastic paraplegia.