Using ICG and ICG-C11 conjugated annexin V, we performed SWIR fluorescence imaging of breast tumor apoptosis induced by treatment of an ADC, trastuzumab emtansine (Kadcyla).23 In this study, we demonstrate that ICG and ICG-C11 conjugated annexin V can be used not only for high-contrast SWIR fluorescence imaging of tumor apoptosis, but also for long-term (ca. two weeks) imaging of tumor apoptosis in living mice. The gene discussed is ANXA5; the disease is neoplasm.