In a similar mouse model, but a different approach to interrupting the CD47-SIRPα signaling, QPCTL deficient Ba/F3-HER2 cells that lack pyroglutamate on CD47, were effectively killed by neutrophils directed to the tumor by IgA-HER2, in a similar fashion to CD47KO Ba/F3-HER2 cells (83). This evidence concerns the gene SIRPA and neoplasm.