Comparison with those in the one specific comorbidity such as DM, hypertension, hyperlipidemia group, the lymphocytes counts and percentages, CD3+ counts and percentages, CD19+ counts and percentages, CD56+ counts and percentages, CD3+CD4+ counts and percentages, CD3+CD8+ counts and percentages, and the ratios of CD3+CD4+ to CD3+CD8+ (Figures 12A–H, 13A–E), were significantly reduced in the specific comorbidity plus another comorbidity group, in the specific comorbidity plus two or more other comorbidities group (P all <0.05). The gene discussed is CD8A; the disease is diabetes mellitus.