In breast cancer cells, these EMT-promoting transcription factors are known to induce the production of GM-CSF and other inflammatory cytokines such as IL-6, IL-8, soluble intercellular adhesion molecule 1 (ICAM1), and plasminogen activator inhibitor 1 (PAI1) (160, 161) and enhance cancer progression. The gene discussed is ICAM1; the disease is breast carcinoma.