TIGIT and HIV-1 infection: To assess the capacity for glucose uptake by CD8 T cells in HIV-1 infection, including exhausted subpopulations, we analysed the expression of Glut-1 directly ex-vivo. Confirming previous observations, PD-1 and TIGIT expression levels were higher on CD8 T cells from viraemic HIV-1 individuals compared to ECs and HIV-1 seronegative controls (Figures 1A, B).