IGF1 and hepatocellular carcinoma: Further, the GH-regulated ABCB1 and IGF1-regulated ABCC1 are significantly and negatively correlated with HCC patient survival (ABCB1: 36 vs. 70 months, Hazard ratio = 1.75, p = 0.0022; ABCC1: 38 vs. 71 months, Hazard ratio = 2.01, p = 5.4e-05) (Figures 5I, J).