ABCG2 and melanoma: Previously, we had identified the highest GHR expression in human melanoma cells in the NCI-60 cell lines (36) and also demonstrated that GH upregulates resistance to doxorubicin, cisplatin, paclitaxel, and vemurafenib by increasing the expression of ABCB, ABCC, and ABCG groups of ABC transporters (28).