GHR and hepatocellular carcinoma: This is particularly important for HCC for two reasons: (i) there is a massive expression of IGF1R following hepatic malignancy while normal liver tissues do not express IGF1R (46), and (ii) normal liver tissue overexpresses GHR and GH induced hepatic IGF1 production accounts for as much as 75-80% of circulating IGF1 (61) – also a paracrine fuel for the tumoral IGF1R.