PTC has a high rate of lymph node metastasis (LNM), the mechanism of which remains unclear; it is presumably associated with multiple genetic and epigenetic alterations, including BRAFV600E, TERT promoter, and phosphoinositol-3 kinase/AKT serine/threonine kinase (PI3K/Akt) pathway (2–5). Here, AKT1 is linked to metastatic malignant neoplasm in the lymph nodes.