In the present study, CREBBP and KMT2D appeared in patients with non-GCB, and inconsistently, CREBBP and KMT2D were mutated more frequently in patients with non-GCB than in PIM1. This illustrates the heterogeneity of lymphoma; there was still a high degree of heterogeneity in lymphomas of the same pathological type. The gene discussed is KMT2D; the disease is lymphoma.