LncRNA DANCR is relatively highly expressed in CD34+ AML primary cells, and knocking down of lncRNA DANCR expression reduces the quiescence and self-renewal of LSCs in vitro and in vivo by down-regulating MYC expression, but not that of normal hematopoietic stem and progenitor cells (HSPCs) (33). The gene discussed is CD34; the disease is acute myeloid leukemia.