Methyltransferase 3(METTL3) increased the translation of downstream leukemia-related genes, such as MYC, BCL2, and PTEN mRNA, in an m6A-dependent manner, and depletion of METTL3 blocked proliferation, induced differentiation, and apoptosis in immunodeficient recipient mice (157). The gene discussed is METTL3; the disease is leukemia.