LncRNA DANCR is relatively highly expressed in CD34+ AML primary cells, and knocking down of lncRNA DANCR expression reduces the quiescence and self-renewal of LSCs in vitro and in vivo by down-regulating MYC expression, but not that of normal hematopoietic stem and progenitor cells (HSPCs) (33). Here, MYC is linked to acute myeloid leukemia.