Other studies also indicated several important dysregulated circRNAs in ESCC, such as circGSK3β, which was associated with metastatic ability of ESCC by enhancing β-catenin signaling (11); hsa_circ_0006168, which was mediated mTOR signaling to handle the progression of ESCC (12); and ciRS-7, which was interacted with MAGE-A family, HOXB13 protein, and epidermal growth factor receptor (EGFR) signaling to manipulate the malignant phenotype of ESCC (13–15). This evidence concerns the gene EGFR and esophageal squamous cell carcinoma.