BDNF and Huntington disease: RNA-seq of i-neurons derived from this same HD line48 and its gene-corrected counterpart as well as from other HD lines harboring 60 and 109 CAG repeats17 revealed more complex gene dysregulation in numerous pathways, such as synapse assembly, axon guidance, neurotrophic signaling, and the brain-derived neurotrophic factor (BDNF) pathway17,48.