As reflected in the data, the concentrations of the BNP (Figure 1F), LDH (Figure 1G), RE (Figure 1H), Ang II (Figure 1I), ALD (Figure 1J), and ET-1 (Figure 1K) of the CHF-modeled rats were significantly increased when compared to those in the Sham group (P < 0.01), while the treatment with paeonol reduced the levels of these markers in these CHF-modeled rats (P < 0.05). This evidence concerns the gene EDN1 and congestive heart failure.