Moreover, we found that DOX inhibited the levels of Bcl-2 and Cyt c (mitochondrion) while promoting the levels of Bax, C-caspase-3, and Cyt c (cytoplasm) in the CHF-modeled rats, but paeonol treatment reversed such effects of DOX (P < 0.05; Figures 2C,D). Here, CASP3 is linked to congestive heart failure.