VCP and inclusion body myopathy with Paget disease of bone and frontotemporal dementia: p97R155H/+ is the most frequently identified p97 disease mutant in IBMPFD patients.60 Therefore, we focused on a patient harbouring p97R155H/+ and generated isogenic WT controls utilizing CRISPR/Cas9 to exclude the effects of genetic background variation.67 In addition, we also made p97R155H/+ from a healthy control WT p97 line.