CASP1 and liver dysplastic nodule: A20 in DN can regulate pyroptosis-mediated podocyte damage by MiR-21-5p in macrophage-derived EVs.Through targeted suppression of A20, miR-21-5p in macrophage-derived EVs can raise the inflammasome NLRP3, caspases-1, and IL-1β associated to pyroptosis, as well as increase the generation of ROS, causing podocyte damage.