Kidney-tubule-specific Mettl3 overexpression induced the occurrence and enlargement of tubular cysts, and conversely, Mettl3 deletion attenuated cyst growth in three different orthologous ADPKD transgenic mouse models, irrespective of the type of PKD1 mutation or dynamics of cyst growth (15). The gene discussed is METTL3; the disease is autosomal dominant polycystic kidney disease.