METTL3 and autosomal dominant polycystic kidney disease: Adenosine methylation at the 6th nitrogen position known as N6-methyladenosine (m6A), recognized as the most common eukaryotic RNA modification and mediated by the multiprotein m6A writer complex composed of Mettl3, etc., was increased in mouse and human ADPKD samples (Figure 1A) (15, 58).