In addition, POLD1 expression was significantly upregulated in HCC tumor when compared with the corresponding liver tissue in TCGA RNA-seq dataset (fold change = 3.15, p < 0.0001) and in our in-house RNA-seq dataset (fold change = 3.26, p < 0.0001) (Figure 5). Here, POLD1 is linked to hepatocellular carcinoma.