These data, together with previous studies of PC activity in mdx mice (Anderson et al., 2003; Kueh et al., 2008; Wu et al., 2022), suggest that information processing through the cerebellar circuit and the output of cerebellar neurons may be impaired by the loss of dystrophin expression, potentially contributing to motor and cognitive deficits observed in DMD. The gene discussed is DMD; the disease is Duchenne muscular dystrophy.