TP53 and gastric cancer: Different drugs have different mechanisms to regulate apoptosis: benzoxanthone compounds regulating the Bcl-2 related protein and the Bcl-2 protein proportion block induced gastric cancer cell apoptosis (Fu et al., 2022), paclitaxel can be through the regulation of p53 gene-mediated apoptosis induced by cell signal transduction pathways (Niapour and Seyedasli, 2022), cisplatin can also through the apoptosis induced by regulating the cell cycle (Guo et al., 2022).