Functional enrichment analysis found that these genes in GC patients, which has a significant impact on immune-related biological processes, primarily manifests in immune response, T-cell activation, T-cell proliferation, neutrophil-mediated immunity, Toll-like receptors (TLRs), HIF-1 signaling pathway, P53 signaling pathway, and neutrophil activation. This evidence concerns the gene TP53 and gastric cancer.