PTEN and posterior cortical atrophy: In mouse lineage-tracing models, loss of the tumor suppressor gene Pten in basal cells promoted basal-to-luminal differentiation, and the resulting tumor had a luminal phenotype (Choi et al., 2012; Wang et al., 2013), resembling the predominant luminal feature in human PCa (Shen and Abate-Shen, 2010).