U-CH1 is a cell model of the rare bone cancer, chordoma, and is associated with the G177D SNV in TBXT. We employed the U-CH1 chordoma cell line, which expresses TBXT at high levels and likely to be in euchromatin, to investigate the functional impact of the G177D SNV (Kelley et al., 2010; Pillay et al., 2012). The gene discussed is TBXT; the disease is bone cancer.