The top among the PPI network analysis included the downregulated HSP90AB1 gene, which encodes a heat shock protein, and its polymorphism has been recently associated with SLE risk and glucocorticoid response [54] Elevated HSP90AB in the serum from SLE patients has been documented, and it is purported to be a key regulator of innate and adaptive responses via controlling signal transduction, protein folding, and transport [55]. The gene discussed is HSP90AB1; the disease is systemic lupus erythematosus.