Ceftriaxone upregulated GLT-1, attenuated ALS manifestations in a mouse model (Rothstein et al., 2005), increased system x(c)(-) and glutathione levels in rat cortical and spinal astrocytes and fibroblasts and hippocampal cell lines, and induced xCT mRNA expression in stem cell-derived human motor neurons (Lewerenz et al., 2009). Here, SLC1A2 is linked to amyotrophic lateral sclerosis.