Furthermore, daily treatment with CEF (200 mg/kg) for 2 months has been reported to attenuate the accumulation of pathological tau, and this effect was associated with increase in GLT-1 expression in the hippocampus in a 3xTg-Alzheimer’s disease mouse model (Zumkehr et al., 2015). This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.