Furthermore, studies reported that focal cerebral ischemia increased glutamate levels and reduced the expression of GLT-1 and xCT in the frontal cortex and hippocampus, and that CEF (200 mg/kg/day) for 5 days pre-cerebral ischemia attenuated these effects (Krzyżanowska et al., 2017). Here, SLC1A2 is linked to brain ischemia.