SLC1A2 and Huntington disease: Moreover, another study demonstrated a decrease in GLT-1 expression in the striatum and cerebral cortex if an HD mouse model compared to wild-type mice at the age of 13 weeks but not 9 weeks, and CEF treatment (200 mg/kg/day) for 5 days restored GLT-1 expression in both brain regions (Sari et al., 2010).