The transcriptional activity of several proinflammatory cytokines/chemokines, such as IL1, IL6, IL8, TNF-α, RANTES, MIF, and ICAM1, is activated by NF-κB signaling, indicating the key role of NF-κB in the inflammatory responses in endometriosis 11, 13, 14, 18, 19, 21-27. The gene discussed is TNF; the disease is endometriosis.