As a commonly used hormone drug for treating endometriosis, progesterone inhibits the NF-κB-induced production of proinflammatory factors in endometriotic cells 46, 47, and the combined use of progesterone and NF-κB inhibitors can remarkably increase the efficacy of alleviating endometriosis-related pain 48. Here, NFKB1 is linked to endometriosis.