NF-κB signaling may also contribute to oxidative stress overload in patients with endometriosis by promoting NOS production and decreasing the expression of antioxidant enzymes, such as superoxide dismutase (SOD), glutathione peroxidase (GPx), heme oxygenase (HO), and catalase (CAT) 35, 57, 58. This evidence concerns the gene CAT and endometriosis.