In PAC, ALKBH5 stymies tumor outgrowth and metastasis by stimulating PER1 transcription in an m6A-YTHDF2-mediated mRNA degradation style, which causes ATM phosphorylation and G2/M arrest by ATM/CHK2/p53/CDC25 signal axis 178. Here, ALKBH5 is linked to neoplasm.