METTL14 and neoplasm: C1q+ TAM subpopulation-specific METTL14 deficiency promotes tumor-infiltrating CD8+T cell dysfunction by reducing cytokine subunit Ebi3 mRNA stability, promoting CD8+T cell exhaustion by increasing Tex cell and increasing Teff cell count, dampening CD8+T cell to eliminate tumors 207 (Figure 4A).