However, it was demonstrated that re-expression of DACT2 inhibited the expression of cyclinB1 and the cyclin B1-Cdk1 (Cyclin-Dependent Kinase 1, also known as cell division control protein kinase 2, CDC2) complex CDC2, and increased the levels of p-CDC2 (Y15) in esophageal and gastric cancers by inhibiting Wnt signaling pathway 51, 53. Here, DACT2 is linked to gastric cancer.