Another study indicated that restored expression of DACT2, the activity of TGF-β/Smad2/3 was suppressed via both proteasome and lysosomal degradation pathways, leading to F-actin rearrangement that might depend on the involvement of cofilin and ezrin-redixin-moesin protein in ESCC 49. This evidence concerns the gene DACT2 and esophageal squamous cell carcinoma.