We found that LCA and INT-777 significantly increased the mRNA expression of TGR5 (Figure 5A) but inhibited the expression of HLA-DR, CD86 and CD40 and the secretion of TNF-α, IL-6, IL-1β and IL-12/p70 (Figures 5B-C). This evidence concerns the gene TNF and Leber congenital amaurosis.