To further determine the association between VIPR1 expression and clinical prognosis of HCC patients, we performed Kaplan-Meier survival analysis of the cohort and found that patients with low VIPR1 expression had worse overall survival (OS) and relapse-free survival (RFS) than those with high VIPR1 expression (Fig. 1E). Here, VIPR1 is linked to hepatocellular carcinoma.