CAV1 and pulmonary arterial hypertension: In separate work using this and other CAV1 variations experimentally, Gairhe et al. demonstrated the important role that CAV1 signaling plays in protecting human pulmonary arterial endothelial cells from many of the pathologic hallmarks of PAH, including exuberant proliferation, impaired apoptosis, dysregulated cellular migration, and perturbed inflammatory response to insult.7