SCN5A and Arrhythmia: The Nav1.5-P1090L has also been associated with Brugada syndrome, sudden infant death syndrome, sick sinus syndrome, and other severe arrhythmia (Ackerman et al., 2004; Lai et al., 2005; Tan et al., 2005; Shan et al., 2008; Zhang et al., 2008; Nakajima et al., 2011; Chiu et al., 2012) (Table 1).