Regarding steatosis, baseline levels of hepatic TGs were higher in the Ppara−/− mice, which is in accord with the phenotype of these mice (Kersten et al., 1999); however, the authors noted that while hepatic TG levels increased to a similar extent after 6 months of alcohol feeding, analysis at earlier time points showed that hepatic TG accumulation was higher in the Ppara−/− mice compared to WT. The gene discussed is PPARA; the disease is steatosis.