On the other hand, UBE2M and OTUB1 were negatively enriched in some cancer-related or immune response-related pathways, such as PI3K/AKT signaling in cancer, the JAK/STAT signaling pathway, pathways in cancer, and the chemokine signaling pathway (Supplementary Figures 5D and 5E). The gene discussed is UBE2M; the disease is cancer.