Low molecular weight rockweed polysaccharide (LMWF), a sulphated polysaccharide derived from brown seaweed with strong anti-inflammatory and antioxidant activities, prevented nonalcoholic fatty liver disease (NAFLD) in db/db mice by activating the Sirt1/AMPK/PGC1α signaling pathway [113], while fucoidan polysaccharides ameliorate renal cell senescence by inhibiting autophagy-related activation of the AMPK-ULK1 signaling pathway through VE-like effects in a D-gal-induced senescence model of human proximal renal tubular epithelial cells. This evidence concerns the gene PPARGC1A and metabolic dysfunction-associated steatotic liver disease.