In the pan‐cancer analysis, compared with normal tissue, ITGB1 is significantly overexpression in various tumors, including stomach adenocarcinoma (STAD), head and neck squamous cell carcinoma (HNSC), esophageal carcinoma (ESCA), cholangiocarcinoma (CHOL) pheochromocytoma and paraganglioma (PCPG), renal clear cell carcinoma (KIRC), and hepatocellular carcinoma (LIHC) (Figure 1A, p < 0.05). This evidence concerns the gene ITGB1 and clear cell renal carcinoma.