WFS1 and autosomal dominant nonsyndromic hearing loss: A total of 3255 variants were presented in Raw data (shown in Additional file 2: Supplementary Table 2), among the 2073 variants that were in heterozygosis, 241 variants had low frequency in the general population databases, 40 variants were located in exons or splicing sites, 3 variants may be associated with autosomal dominant deafness (shown in Additional file 3: Supplementary Table 3), 2 variants in the WFS1 gene didn't segregated with the affected status in this family (shown in Additional file 1: Supplementary Fig. 3).