The mitochondrial metabolism also generates oncometabolites such as (R)-2-hydroxyglutarate (2-HG) via isocitrate dehydrogenase (IDH) mutation in acute myeloid leukemia (AML), succinate via mutation succinate dehydrogenase (SDH), and fumarate via mutation in fumarate hydratase (FH), which promote tumor growth and progression [3, 30, 31]. Here, FH is linked to neoplasm.