All these activities require plenty of energy, especially mitochondrial ATP [19, 20] However, it was found in a systemic immunosuppressive property (SIP) tumor model [21] that atypical and non-proteinaceous molecules less than 3 kDa released from SIP-positive tumor cells could weaken mitochondrial energy metabolism and proliferation of CD8+ T cells, thus favoring SIP-positive tumor cells to escape anti-tumor immune response CD8+ T cells. The gene discussed is CD8A; the disease is neoplasm.