AKT1 and colorectal carcinoma: Some gene mutations including APC, TP53, SMAD4, KRAS, and several altered molecular signaling pathways are also involved in CRC onset, such as DNA mismatch repair, Wnt/β-catenin, TGF-β/Smad, RAS-MAPK, PI3K/AKT, NF-κb and c-Myc signaling [7–11].