We then examined the expression of MAGI3 on c-Myc protein stability, and found that the half-life of c-Myc protein was markedly decreased with MAGI3 overexpression (Fig. 3f and Additional file 4: Fig. S3A) and significantly increased by knockdown of MAGI3 in CRC cells (Fig. 3g and Additional file 4: Fig. S3B). Here, MYC is linked to colorectal carcinoma.